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CAUSES OF HERPES Herpes is caused by either of two viruses that are transmitted by direct contact. Once established, the virus remains dormant in the body, and activates during times of stress. Herpes is caused by two types of herpes simplex virus (HSV): HSV-type 1 (HSV-1) and HSV-type 2 (HSV-2). Either virus can cause blisters in the mouth or genital region, but HSV-2 typically affects the genitals, whereas HSV-1 most commonly affects the mouth.